Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug DevelopmentArticle Published on 2022-11-142022-11-15 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료기술, 치료제, [키워드] binding binding site Chemical chemotypes Comprehensive Consensus COVID19-NMR development drug drug design Drug discovery fragment fragment screening functional identify International Intervention Ligand NMR NMR spectroscopy novel performed predict protease Protein Proteins proteome protocol provide public health RNA genome SARS-CoV-2 SARS-CoV-2. Screening Space the SARS-CoV-2 Vaccines variant variants of concern was used [DOI] 10.1002/anie.202205858 PMC 바로가기
Modeling the Enzymatic Mechanism of the SARS-CoV-2 RNA-Dependent RNA Polymerase by DFT/MM-MD: An Unusual Active Site Leading to High Replication RatesArticle Published on 2022-09-122022-11-15 Journal: Journal of Chemical Information and Modeling [Category] SARS, 유전자 메커니즘, 치료제, [키워드] absence Activation Antiviral assist cellular compensated computation COVID-19 diffusion duplication Efficiency Enzymes highlight histidine Inclusion infecting Infection lack leading less Lower lysine mechanism modeling nucleotide Pandemics performed polymerase polymerases Rate reactive reactivity Replication replication of SARS-CoV-2 RNA RNA genome RNA viruses RNA-dependent RNA polymerase SARS-CoV-2 genome Site subsequent the SARS-CoV-2 viral genome Viral RNA virus [DOI] 10.1021/acs.jcim.2c00802 PMC 바로가기
Structural investigations of proteins encoded by SARS-CoV-2Article Published on 2022-09-012022-11-16 Journal: FEBS Open Bio [Category] SARS, 변종, 유전자 메커니즘, [키워드] antibodies articles bases categories cellular cleaved commenced coronavirus COVID COVID-19 pandemic cysteine proteases described ENCODE Evolution example expressed Final Genome include knowledge MN908947.3 molecular mechanism other coronaviruses pandemic polyprotein positive-sense Protein protein structure purified reported Research ribonuclease RNA genome RNAs SARS-CoV-2 selected sequenced single-stranded small molecule drugs Spike protein spike protein. structural property the disease the spike protein translation Vaccines variant viral transcript were expressed [DOI] 10.1002/2211-5463.13465 PMC 바로가기
SARS-CoV-2 nsp14 Exoribonuclease Removes the Natural Antiviral 3′-Deoxy-3′,4′-didehydro-cytidine Nucleotide from RNASARS-CoV-2 nsp14 엑소리보뉴클레아제는 RNA에서 천연 항바이러스성 3'-데옥시-3',4'-디데하이드로-시티딘 뉴클레오타이드를 제거합니다Article Published on 2022-08-162022-09-11 Journal: Viruses [Category] SARS, 변종, 유전자 메커니즘, 치료제, [키워드] 3'-dCTP analogues Antiviral antiviral drug Antiviral effect biochemically caused Chain terminator COVID-19 cytidine 5'-monophosphate ddhCTP Efficacy enzyme ExoN Exoribonuclease facilitate feature global pandemic innate immune response mechanism monophosphate natural natural antiviral non-structural protein nsp14 nucleoside nucleoside analogue nucleotide nucleotide analogues nucleotides produced Proofreading proofreading. RdRP Remove Replication RNA RNA genome RNA polymerase RNA synthesis RNA-dependent RNA polymerase SARS-CoV-2 susceptible termination the SARS-CoV-2 viral infections Viral RNA [DOI] 10.3390/v14081790 PMC 바로가기 [Article Type] Article
The mechanism of RNA capping by SARS-CoV-2 Research Published on 2022-08-092022-10-05 Journal: Nature [Category] SARS, 유전자 메커니즘, [키워드] analysis Antiviral complex COVID-19 domain exonuclease facilitate functional GDP genetics group Host immune Interaction mechanism methyltransferase N terminus nidovirus non-structural protein Nsp12 Nsp9 Nsps required residue RNA RNA genome SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA structures transfer translation treat Viral proteins [DOI] 10.1038/s41586-022-05185-z [Article Type] Research
Convolutional Neural Network Applied to SARS-CoV-2 Sequence ClassificationSARS-CoV-2 서열 분류에 적용된 컨볼루션 신경망Article Published on 2022-07-312022-09-11 Journal: Sensors (Basel, Switzerland) [Category] COVID19(2023년), SARS, 변종, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition approach Biotechnology cause caused center classification CNN Containment Contamination Convolutional neural network coronavirus COVID-19 deaths deep learning deep learning. family genome sequence genomic sequence Health Organization instance limit mortality rate Mutation NCBI network Neural omicron Omicron variant organism outbreak pandemic parameters performed positive-sense RNA genome SARS-CoV-2 sequence sequences severe acute respiratory syndrome Coronavirus Spread subgenus subsequent the disease Transmission Treatment variant virus virus viruses World Health Organization [DOI] 10.3390/s22155730 PMC 바로가기 [Article Type] Article
A qualitative RT-PCR assay for the specific identification of the SARS-CoV-2 B.1.1.529 (Omicron) Variant of ConcernSARS-CoV-2 B.1.1.529(Omicron) 변형 우려의 특정 식별을 위한 정성적 RT-PCR 분석Article Published on 2022-07-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Alpha Alpha variant Alpha VOC B.1.1.529 B.1.1.7 B.1.351 B.1.429 B.1.526 B.1.617.1 B.1.617.2 Beta can be used circulating clinical sample clinical samples collected Combination concern copy numbers Delta detect develop Epsilon Gamma Genome in silico Iota lineages negative controls non-specific omicron P.1 performed positive replaced REPLACED BY RNA RNA genome RT-PCR RT-PCR assay SARS-CoV-2 Sequencing Specific Specific identification. specificity the SARS-CoV-2 variant virus VoC were used Wuhan [DOI] 10.1016/j.jcv.2022.105191 PMC 바로가기 [Article Type] Article
SARS-CoV-2, SARS-CoV, and MERS-CoV encode circular RNAs of spliceosome-independent originSARS-CoV-2, SARS-CoV 및 MERS-CoV는 spliceosome-independent origin의 원형 RNA를 인코딩합니다.Article Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] Coronavirus, COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] abundance acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplified analysis Analysis approaches assays Autoimmune disease Autoimmune diseases betacoronavirus betacoronaviruses breakpoint canonical Chain Reaction characterized Circular circular RNA complementary coronavirus Critical cytoplasmic demonstrated distribution Features Fluorescence highlight homologous Host In situ hybridization infected Vero E6 cells junction mechanism MERS-CoV Middle East Middle East respiratory syndrome Coronavirus N gene not limited offer polymerase chain polymerase chain reaction predicted probe respiratory syndrome coronavirus RNA RNA Biology RNA genome RNA genomes RNA sample RNA samples RNA synthesis RNase SARS-CoV SARS-CoV-2 sequenced severe acute respiratory syndrome Coronavirus transcriptional regulatory sequences Transcriptome Vero E6 VERO E6 cells viral pathogenesis viral transcriptome Virology Virology. [DOI] 10.1002/jmv.27734 PMC 바로가기 [Article Type] Article
Basic virology of SARS-CoV 2SARS-CoV 2의 기본 바이러스학Review Published on 2022-04-012022-09-11 Journal: Indian journal of medical microbiology [Category] Coronavirus, COVID19(2023년), SARS, 치료법, [키워드] 229E acute respiratory disease acute respiratory syndrome acute respiratory syndrome coronavirus basic bats bind cats Cell cell surface cellular membrane Characteristics clinical manifestation coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID 19 COVID-19 disease envelope Exocytosis followed by fusion Genome genomic genomic RNA global public health helical symmetry HKU1 host cell host cell cytosol hosts human coronaviruses humans Immunological response Infection mammalian membrane MERS MERS-CoV Mild NL63 nucleocapsid OC43 pandemic Pathogenesis pathogenic pathogenic coronavirus positive Protein receptor Receptor binding released RNA genome RNA synthesis S protein SARS CoV SARS CoV-2 SARS-CoV 2 SARS-CoV-2 Seven severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spread structural proteins the S protein translation transported Vesicle vesicles viral genome viral genomic RNA viral replication virion virions Virology Virology. virus [DOI] 10.1016/j.ijmmb.2022.02.005 PMC 바로가기 [Article Type] Review
Secondary structural ensembles of the SARS-CoV-2 RNA genome in infected cells Research Published on 2022-03-022022-10-05 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] average Betacoronavirus canonical cellular conformation coronavirus RNA COVID-19 pandemic Critical full length functional Genome genomic structure heterogeneity highlight infected cell lack much higher positive-sense promote reported responsible RNA RNA genome SARS-CoV-2 SARS-CoV-2 genome secondary secondary structure single nucleotide single-stranded Structure the SARS-CoV-2 [DOI] 10.1038/s41467-022-28603-2 [Article Type] Research